oligodendroglioma pathology outlines

As for the clinical relevance of these molecular markers, inactivating mutations affecting FUBP1 have correlated with a shorter time to recurrence and CIC mutations have been associated with worse prognosis, especially in those patients with 1p/19q co-deleted oligodendrogliomas (Chan et al., 2014; Michaud et al., 2018). (Jan 2013). A phase II study of intravenous carboplatin for the treatment of recurrent gliomas. (WC/jensflorian), Demonstration of IDH1 R132H mutation in oligodendroglioma. 0000230069 00000 n (2017). Oligodendroglioma. IDH mutations can dominantly inhibit WT-IDH when heterozygous through the formation of enzymatically inactive heterodimers (Zhao et al., 2009). Advances in the biology and treatment of oligodendrogliomas. Moreover, no mutations were found in ERCC6 exon 2 and only two patients had a chemotherapeutic response, but with unexpected short survival times. Alattar et al. Clin Cancer Res. (2010). (2007). The CODEL study is a phase 3 study whereby 36 patients with newly diagnosed grade III oligodendrogliomas were randomized to receive RT alone (Arm A), RT with concomitant and adjuvant TMZ (Arm B) or TMZ alone (Arm C) (Jaeckle et al., 2021). Oligodendroglioma - Wikipedia 43, 7178. There was however no such benefit for CIMP- or for MGMT-STP27 unmethylated tumors. Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system. (2013). In this review article, we describe the clinical management of AO and summarize the different molecular pathways that drive the development, maintenance, and treatment response of these tumors. J. Clin. Oligodendroglioma is a growth of cells that starts in the brain. Sometimes surgery can't be done if the tumor is in a part of the brain that makes it hard to access with surgical tools. Accounting to up to 5% of all neuroepithelial tumors ( Ostrom et al., 2017 ), oligodendroglial tumors have an incidence rate of around 1,000 new cases per year in the United States. Neurobiol. doi: 10.1101/gad.294991.116, Ascierto, P. A., McArthur, G. A., Drno, B., Atkinson, V., Liszkay, G., Di Giacomo, A. M., et al. Low-grade oligodendroglioma responds to chemotherapy. doi: 10.1371/journal.pone.0163067. J Pathol. (2000b). No use, distribution or reproduction is permitted which does not comply with these terms. (2002). Lately, IDH 1 and 2, which are known to generate nicotinamide adenine dinucleotide phosphate (NADPH), have been heavily observed. 7(4):305-314. Mayo Clinic does not endorse companies or products. Treat. Cancer Res. Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas. Oncol. Macdonald, D., Cairncross, G., Stewart, D., Forsyth, P., Sawka, C., Wainman, N., et al. (2006). 57(2):172-5. For unequivocal assessment of 1p/19q codeletion in oligodendroglial tumors, detection of whole-arm losses is key. Brain Tumors in Adults. doi: 10.3171/2011.3.JNS1153, Fan, Q.-W., and Weiss, W. A. Molecules 24:968. doi: 10.3390/molecules24050968, Killela, P. J., Reitman, Z. J., Jiao, Y., Bettegowda, C., Agrawal, N., and Diaz, L. A. Jr. et al. 71-82. van den Bent MJ, Afra D, de Witte O, et al. 59, 495503. The European Organization for Research and Treatment of Cancer study 26951 (EORTC26951) and RTOG9402 showed an increase in OS and PFS when PCV is added to radiotherapy (RT) in patients with 1p19q co-deleted oligodendrogliomas (Cairncross et al., 2013; van den Bent et al., 2013a). A Phase II study of paclitaxel in patients with recurrent malignant glioma using different doses depending upon the concomitant use of anticonvulsants: a North American Brain Tumor Consortium report. Brandes, A. However, upon multivariate analysis there was no significant difference in overall survival (OS). Oligodendrogliomas usually appear as a single tumor with well-defined borders. Molecular subtypes of anaplastic oligodendroglioma: implications for patient management at diagnosis. 0000015277 00000 n [Full Text]. Cancer. Wick, W., Hartmann, C., Engel, C., Stoffels, M., Felsberg, J., Stockhammer, F., et al. Jaeckle KA, Ballman KV, van den Bent M, Giannini C, Galanis E, et al. If you log out, you will be required to enter your username and password the next time you visit. With proper education, the patient and family can develop good insight into the course and prognosis of the tumor. (1994). [QxMD MEDLINE Link]. (2013a). 2008 Aug. 15(8):946-9. PDF Oligodendroglioma and Oligoastrocytoma - abta.org 0 Yip S, Butterfield YS, Morozova O, Chittaranjan S, Blough MD, An J, Birol I, Chesnelong C, Chiu R, Chuah E, Corbett R, Docking R, Firme M, Hirst M, Jackman S, Karsan A, Li H, Louis DN, Maslova A, Moore R, Moradian A, Mungall KL, Perizzolo M, Qian J, Roldan G, Smith EE, Tamura-Wells J, Thiessen N, Varhol R, Weiss S, Wu W, Young S, Zhao Y, Mungall AJ, Jones SJ, Morin GB, Chan JA, Cairncross JG, Marra MA. 9, 860864. Case Report: Single-Cell Transcriptomic Analysis of an Anaplastic Oligodendroglioma Post Immunotherapy. Salvage chemotherapy with paclitaxel for recurrent primary brain tumors. 2004 Dec. 17(6):675-80. PNETs may also have some swelling around them. Results of this trial raise the possibility that the chemosensitivity seen in these tumors might be due to the IDH mutation that is common to both oligodendroglial and low-grade astrocytic gliomas. An estimated 11,757 people are living with this tumor in the United States. 100, 22352241. Genetic alterations and signaling pathways in the evolution of gliomas. ; Sahm, F.; Schrimpf, D.; Wiestler, B.; Capper, D.; Koelsche, C.; Schweizer, L.; Korshunov, A. et al. Neuro Oncol. 0000126977 00000 n 2005 May. The .gov means its official. (2006). During this type of surgery, you're awakened from a sleep-like state. 18:636. doi: 10.1200/jco.2000.18.3.636, Smith, J. S., Wang, X.-Y., Qian, J., Hosek, S. M., Scheithauer, B. W., Jenkins, R. B., et al. Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogliomas and oligoastrocytomas: a randomized European Organisation for Research and Treatment of Cancer phase III trial. Infiltration of these cells might have been perceived as the increased mass on MRI. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate Dang L, White DW, Gross S, et al. A., Taphoorn, M. J., Kros, J. M., Kouwenhoven, M. C., Delattre, J.-Y., et al. Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas. (2013b). Oligodendroglioma is a primary central nervous system (CNS) tumor. Stephen A Berman, MD, PhD, MBA is a member of the following medical societies: Alpha Omega Alpha, American Academy of Neurology, Phi Beta KappaDisclosure: Nothing to disclose. 2005 Sep 17-23. Table 1 outlines some information related to the major drugs used in treatment. This was attributed to the sensitivity of oligodendrogliomas to chemotherapy compared to astrocytomas (Alattar et al., 2018). Neuro. In giant cells gliomas, giant cells were GFAP negative or weakly positive. J Clin Oncol. (2011). Delays in diagnosis are likely to occur given the nature of pediatric oligodendroglioma. The brain surgeon, who is also called a neurosurgeon, works to remove the tumor without harming healthy brain tissue. 10, 139144. 0000255421 00000 n (2016). doi: 10.1212/01.wnl.0000262034.26310.a2, Kaminska, B., Czapski, B., Guzik, R., Krl, S. K., and Gielniewski, B. While often found upregulated in many tumors, FUBP1 acts as a tumor suppressor gene due to its inactivating mutations reported in around 15% of oligodendroglial tumors (Baumgarten et al., 2014). Jaeckle, K. A., Ballman, K. V., van den Bent, M., Giannini, C., Galanis, E., Brown, P. D., et al. [QxMD MEDLINE Link]. doi: 10.3171/JNS/2008/109/11/0835, Sherr, C. J., and Roberts, J. M. (1999). While usually unexpressed in mature cells, cancer cells make use of this enzyme to promote their survival and increase proliferation. Elsewhere, another phase 1 study (NCT02644291) is assessing the use of mebendazole in recurrent/progressive pediatric brain tumors of 21 participants. JNS 128, 10761083. Neurology 46, 203207. [QxMD MEDLINE Link]. J. doi: 10.1038/nature10898. 1987 Apr 1. Newly diagnosed oligodendroglioma, IDH-mutant and 1p19q codeleted. Contents 1 General 2 Gross/radiologic 3 Microscopic 3.1 Images 3.2 Histologic grading 4 IHC hTmlSe~j;6Gam!fM7[7r2N|77`" 5@!1a?H~hIOu(99}oyHsV`X~+|vQ- (2001) reported that 16.7% of patients experienced a complete response and 27.1% experienced a partial response when receiving temozolomide (TMZ) after previous PCV. J. Neurooncol. Primitive Neuro-Ectodermal Tumors (PNET) Diagnosis and Treatment CODEL: phase III study of RT, RT+ TMZ, or TMZ for newly diagnosed 1p/19q codeleted oligodendroglioma. The frequency of these alterations was much higher in grade III AO as compared to grade II oligodendroglioma. JmjC demethylases are one of the many dioxygenases regulated by -KG and inhibited by 2-HG. Low-risk patients have a better prognosis than high-risk patients. The relative 5-year survival rate for oligodendroglioma is 74.1% but know that many factors can affect prognosis. Retrospective studies have clearly defined the most common presenting symptoms and tumor locations. (WC/jensflorian), Minigemistocytes and mitoses. A t(1;19)(q10;p10) mediates the combined deletions of 1p and 19q and predicts a better prognosis of patients with oligodendroglioma. doi: 10.1093/neuonc/now133, Xu, W., Yang, H., Liu, Y., Yang, Y., Wang, P., Kim, S.-H., et al. Insulator dysfunction and oncogene activation in IDH mutant gliomas. Neurosurgery. 21(13):2525-8. (1991). Roger E McLendon, MD Professor, Director of Surgical Pathology, Chief of Neuropathology, Department of Pathology, Duke University Medical Center doi: 10.1007/s11060-012-0946-9, Carbonneau, M., Gagn, L. M., Lalonde, M.-E., Germain, M.-A., Motorina, A., Guiot, M.-C., et al. Genes may be mutated (changed) in many types of cancer, which can increase the growth and spread of cancer cells. Postoperative radiotherapy (XRT) to a total dose of roughly 60 Gy over 30 fractions is recommended (Blakeley and Grossman, 2008). outline, and implementation are described in the previous article of the series in this issue. 21, 251255. PNETs usually initially appear as a single mass in the cortex, the outer layer of the brain. Ann Neurol. ROS and brain gliomas: an overview of potential and innovative therapeutic strategies. PCV and TMZ are also used in cases of recurrence but result in lower response rates and disease-free survival. Better prognosis compared to astrocytic tumors. At the molecular level, 9p losses result in the loss of the cyclin-dependent kinase inhibitor CDKN2A gene, which normally inhibits cellular division. 0000000016 00000 n Oligodendrogliomas. (2016). Res. [QxMD MEDLINE Link]. www.pathologyoutlines.com/topic/stainsolig2.html, Mozilla/5.0 (iPhone; CPU iPhone OS 15_5 like Mac OS X) AppleWebKit/605.1.15 (KHTML, like Gecko) GSA/218.0.456502374 Mobile/15E148 Safari/604.1. eCollection 2022. (2012). Boston: Butterworth Heinemann; 1997. :: BTRT :: Brain Tumor Research and Treatment doi: 10.1007/s00401-016-1545-1, Lu, C., Ward, P., Kapoor, G., Rohle, D., Turcan, S., Abdel-Wahab, O., et al. [QxMD MEDLINE Link]. "Molecular pathology of oligodendroglial tumors.". J. Neuropathol. Lower grade gliomas. PLoS One 11:e0163067. Elefante A, Peca C, Del Basso De Caro ML, Russo C, Formicola F, Mariniello G, et al. A rare, giant, anaplastic oligodendroglioma. Rodriguez, FJ. Click. 0000013354 00000 n 2022 Nov 22;15(3):e23. It has also been reported that 2-HG can inhibit p53 via microRNA activated by HIF-2, driving tumorigenesis (Jiang et al., 2018). Some subtypes +ve - should not be used to distinguish. CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas. The wildtype (WT) TERT group was associated with good prognosis only in IDH1/IDH2 WT (IDH-WT) grade II/III astrocytomas. The end result is DNA hypermethylation and thus the blockage of cellular differentiation (Kaminska et al., 2019). Randomized Trial of Radiation Therapy Plus Procarbazine, Lomustine, and Vincristine Chemotherapy for Supratentorial Adult Low-Grade Glioma: Initial Results of RTOG 9802. Grade III oligodendroglioma show a worse prognosis than grade II tumors due to the presence of anaplastic features such as nuclear atypia, necrosis, microvascular proliferation, high cell density and number of mitotic figures. (2017). Molecular alterations associated with tumor progression: Glioma CpG island methylator phenotype (G CIMP) (.
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