turkey tail mushroom pancreatic cancer

See additional information. There have been some studies done on turkey tail mushrooms for cancer. Oncol Rep 27 (4): 1079-89, 2012. In Japan, turkey tail has been used to strengthen the immune system when given with standard cancer treatment. Hiroshima J Med Sci 59 (1): 1-6, 2010. replace or update an existing article that is already cited. : DNA barcoding for identification of consumer-relevant mushrooms: A partial solution for product certification? It has been show to inhibit . Thanks to turkey tail mushrooms, you'll have a better immune system, lower cholesterol, and a decreased cancer risk. : Ganoderma lucidum derived ganoderenic acid B reverses ABCB1-mediated multidrug resistance in HepG2/ADM cells. Limited research suggests that a component of turkey tail called protein-bound beta-glucan (PBG) could help prevent obesity. Among the biologically active components of G. lucidum are triterpenoids, polysaccharides, lipids, and proteins. Taking any mushroom extract could cause a life threatening reaction in some people. [13] The activity is considered to be immunomodulatory in nature, similar to many other medicinal fungi. PSK is not a homogeneous substance, with a range of molecular weights averaging 9.4 kDa (range 5300 kDa). Cheng CR, Yang M, Yu K, et al. : Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer. This section describes the latest changes made to this summary as of the date above. The best-studied Ganoderma polysaccharides possess mostly 1,3- and 1,4-glycosidic linkages, which are of high molecular weight. A quick look at cancer cell death is a perfect example. Sun LX, Li WD, Lin ZB, et al. We avoid using tertiary references. : Distinguishing commercially grown Ganoderma lucidum from Ganoderma lingzhi from Europe and East Asia on the basis of morphology, molecular phylogeny, and triterpenic acid profiles. Fungi: Mushroom Science XIX. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. These mushrooms have been around for hundreds of years, says Santhosshi Narayanan, M.D., a physician in MD Andersons Integrative Medicine Center. Turkey tail mushrooms act as nonspecific immune modulators In the United States, dietary supplements are regulated as foods, not drugs. It was also revered in Japanese culture. The FDA has not approved the use of medicinal mushrooms as a treatment for cancer or any other medical condition. People in the United States may respond differently than people in China and Japan because our metabolism may be different. PDQ is a registered trademark. Turkey tail extracts have been used in Japan for decades as an adjuvant (additional) therapy for cancer treatments. : Effects of preoperative immunochemoradiotherapy and chemoradiotherapy on immune responses in patients with rectal adenocarcinoma. Despite decades of study, the mechanisms at work here remain unclear. In fact, one 2017 study found that turkey tail mushrooms have 35 different phenolic compounds. Mushrooms can strengthen the immune system To assist readers in evaluating the results of human studies of integrative, alternative, and complementary therapies for cancer, the strength of the evidence (i.e., the levels of Turkey tail is a woody bracket polypore fungus that grows on dead logs worldwide. Learn more about the potential benefits, as well as the risks, in the following articles: Turkey tail mushrooms are generally considered safe and possibly even helpful. Analytical studies have examined the relative amounts of the different triterpenes in fruiting bodies, as well as in mycelial preparations. Some studies have shown that cancer patients who take mushrooms may live longer. That is what researchers from Singapore aim to find out. Liang Z, Yi Y, Guo Y, et al. This type of cancer develops. PSK has been used as an adjunctive cancer treatment in thousands of patients since the mid-1970s. Because dietary supplements are not formally reviewed for manufacturing consistency, ingredients may vary considerably from lot to lot and there is no guarantee that ingredients claimed on product labels are present (or are present in the specified amounts). Is the ketogenic diet right for autoimmune conditions? Have an open conversation with your care team about the pros and cons, as well as the limitations of the research we have.. Symptoms, Treatment and Diet for Pancreatic Cancer | addon.life The Lyda Hill Cancer Prevention Center provides cancer risk assessment, screening and diagnostic services. : Identification of commercial Ganoderma (Lingzhi) species by ITS2 sequences. : Ganoderma lucidum polysaccharides can induce human monocytic leukemia cells into dendritic cells with immuno-stimulatory function. There is a trend toward improved quality of life shown in the research, but we cant pinpoint the exact reason, says Narayanan. You might spot one of these colorful mushrooms, which can resemble a series of discs, growing out of the side of a hardwood tree. high blood pressure. Expert Opin Investig Drugs 22 (8): 981-92, 2013. Mushrooms have been linked to improvements in several common quality of life indicators for cancer patients. : Recombinant Lz-8 from Ganoderma lucidum induces endoplasmic reticulum stress-mediated autophagic cell death in SGC-7901 human gastric cancer cells. If you are ready to make an appointment, select a button on the right. As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. [17] Unfortunately, the chemotherapy regimens differed in that the PSK patients were treated with fluorouracil and mitomycin-C (207 patients), while the controls received fluorouracil with doxorubicin-based chemotherapy (103 patients), introducing a potential bias in the interpretation of the results. Rather, it may be a useful addition to a medical treatment plan, under a doctors supervision and with their approval. link.springer.com/article/10.1186/s12906-019-2681-7, accp1.onlinelibrary.wiley.com/doi/abs/10.1177/009127000204200904, journals.sagepub.com/doi/full/10.1177/1534735415572883, ncbi.nlm.nih.gov/pmc/articles/PMC4684115/, link.springer.com/chapter/10.1007/978-981-13-6382-5_7, spandidos-publications.com/10.3892/ijmm.2013.1378, ncbi.nlm.nih.gov/pmc/articles/PMC6010034/, ncbi.nlm.nih.gov/pmc/articles/PMC6367522/, ncbi.nlm.nih.gov/pmc/articles/PMC2845472/, Curing Cancer: Newer Treatments to Keep an Eye On, Cancer Treatment at Home: What to Ask Your Doctor, Pancreatic Cancer May be Caused by This Killer Protein, What to Know About Cancer in the Lymph Nodes of Your Neck. 2023 Healthline Media UK Ltd, Brighton, UK. Their inclusion should not be viewed as an endorsement of the content of the websites, or of any treatment or product, by the PDQ Integrative, Alternative, and Complementary Therapies Editorial Board or the National Cancer Institute. Turkey tail mushrooms contain compounds called polysaccharopeptide (PSP) and polysaccharide-K (PSK). 2023 The University of Texas MD Anderson Chilton J: A new analytical fingerprinting system for quality control of medicinal mushroom products. The team did not conduct the study in humans. Learn more about beta glucan supplements, their benefits and risks. Sakagami H, Aoki T, Simpson A, et al. Proceedings of the 19th Congress of the International Society Conclusion Pancreatic Cancer Incidence Pancreatic cancer is the cancer that starts in the pancreas, a gland producing digestive juices and hormones. as reference 23). The patients were treated with chemotherapy or radiation therapy, and other complementary therapies. More Wang T, Xie ZP, Huang ZS, et al. In animal models, direct antitumor effects resulted in reduced tumor growth and metastases. The 5-year DFS was 0.72 (95% CI, 0.580.90; The 5-year OS was 0.71 (95% CI, 0.550.90; Carlson A, Justo A, Hibbett DS: Species delimitation in Trametes: a comparison of ITS, RPB1, RPB2 and TEF1 gene phylogenies. Methods Enzymol 548: 93-116, 2014. Always follow the dosage instructions carefully. The best known constituent of turkey tail is the glycoprotein mixture known as PSK. For example, turkey tail mushrooms are high in antioxidants like phenols. 5-y survival: : Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities. More Information : Triterpene-loaded microemulsion using Coix lacryma-jobi seed extract as oil phase for enhanced antitumor efficacy: preparation and in vivo evaluation. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. In Japan and China, certain mushrooms are routinely used to complement cancer treatments. Request an appointment at MD Anderson online or by calling 1-877-632-6789. Our website services, content, and products are for informational purposes only. An increase in peripheral blood NK cells after therapy was observed in the PSK-treated group compared with the control group. If you have questions about MD Andersons appointment process, our information page may be the best place to start. Jin X, Ruiz Beguerie J, Sze DM, et al. All rights reserved. A study in mice, for example, found that PBG helped prevent weight gain in those that ate a high fat diet. 751; 376; 374 This summary is written and maintained by the PDQ Integrative, Alternative, and Complementary Therapies Editorial Board, which is [1-5] The newly accepted name for the East Asian species traditionally called G. lucidum is Ganoderma sichuanense. However, turkey tail extract does not treat cancer on its own. Turkey Tail mushrooms and our personal fight against cancer While there are currently trials underway, the FDA has refused to approve the use of PSK as a cancer treatment. In one 2019 study, a team of researchers reviewed 23 clinical trials involving more than 4,200 patients. The glycoprotein molecules are composed of a main chain beta-(1,4) glucan with beta-(1,3) and beta-(1,6)linked side chains. Cochrane Database Syst Rev 6: CD007731, 2012. Standish LJ, et al. The G. lucidum polysaccharides were isolated from a boiling water extract of G. lucidum fruit bodies by ethanol precipitation. Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curative resections of gastric cancer. The extract also seemed to improve other aspects of the patients progress, including body weight, immune function, and quality of life. Although this was not a randomized trial, baseline characteristics of the patients were well matched. Coriolus versicolor or Turkey Tail mushroom is one such compound with some impressive research-backed benefits for cancer patients. Upton R, ed. . More information about contacting us or receiving help with the Cancer.gov website can be found on our Contact Us for Help page. Hence, these results contradict the findings from the Korean analysis. Ganoderenic acid B, a G. lucidum derived triterpene, has been shown to enhance the cytotoxicity of chemotherapeutic agents in a drug-resistant cell line of hepatocellular carcinoma by inhibiting the transport function of the adenosine triphosphate (ATP)-binding cassette (ABC) superfamily transporters. Boh B: Ganoderma lucidum: a potential for biotechnological production of anti-cancer and immunomodulatory drugs. Researchers continue to examine the potential of using extract or treatments derived from turkey tail mushrooms to prevent or treat several kinds of cancer. Another study that looked at the use of extracts derived from two types of mushrooms, including turkey tail mushrooms, found promise in treating colon cancer cells. Cheng CR, Yue QX, Wu ZY, et al. [20], Several G. lucidum-derived products have been studied in preclinical models and reported to produce anticancer effects. Its also good to keep in mind that the FDA doesnt regulate supplements like this. Researchers have yet to identify any severe side effects associated with turkey tail. Interested in learning about other natural treatments for cancer and cancer prevention? Research may not translate to patients in the United States. Prostate Cancer: Why More People are Turning to Monitoring Instead of Treatment, digestive upset, such as diarrhea, gas, or bloating. Polysaccharide K and Coriolus versicolor extracts for lung cancer: A systematic review. Liang C, Li H, Zhou H, et al. lung cancer models using either PSK or other T. versicolor Shiitake mushrooms are the only one of these that can easily be bought whole in grocery stores. Most are for prostate, breast and colorectal cancers. : Ganoderiol A-enriched extract suppresses migration and adhesion of MDA-MB-231 cells by inhibiting FAK-SRC-paxillin cascade pathway. PLoS One 7 (6): e39343, 2012. And some evidence suggests that turkey tail mushrooms may have anticancer properties. In Japan, PSK is an . 2023 Healthline Media LLC. It is intended as a resource to inform and assist clinicians in the care of their patients. Coriolus versicolor and Ganoderma lucidum related natural products as an adjunct therapy for cancers: A systematic review and meta-analysis of randomized controlled trials. However, research is ongoing on the potential benefits of reishi mushrooms. However, CD57-positive T cells decreased more significantly after surgery for patients treated with PSK than for those in the control group (P = .0486). The 3-year relapse-free survival rates were 76.2% in the PSK group and 47.8% in the UFT-only group (control), and the 3-year OS rates were 80.8% in the PSK group and 52.8% in the control group.[24]. In: Baars JJP, Sonnenberg ASM, eds. PLoS One 8 (10): e76620, 2013. (2019). But it's. While the mechanism of action for PSK in general and in colorectal cancer specifically is not clearly defined, the potential activity of PSK as an immunomodulatory adjunct to chemoradiation therapy in rectal cancer has been studied. The compounds in turkey tail may also offer benefits for gut health. Oka S, Tanaka S, Yoshida S, et al. Int J Mol Med 32 (1): 251-7, 2013. high cholesterol. Sakai T, Yamashita Y, Maekawa T, et al. The soil or the area around the mushroom could be contaminated with pollutants or bacteria. What is the nutritional value of mushrooms? Turkey tail mushrooms can help you strengthen your immune system and fight off cancer cells. Knežević A, et al. : Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-beta1 from prostate cancer cells. Acta Pharm 61 (3): 335-42, 2011. It has been used to validate the presence of PSK in implanted tumors. The rest are often found in powdered forms in health food stores. The authors concluded that PSK adjuvant immunotherapy may be effective in MHC class Inegative patients with advanced lymph node metastasis of pN2 or greater. Turkey tail mushrooms contain compounds called polysaccharopeptide (PSP) and polysaccharide-K (PSK). Some evidence suggests that PSP may also have the ability to stimulate the immune system, especially when combined with other anticancer treatments. Ito G, Tanaka H, Ohira M, et al. Mar 15, 2023. The activity is generally considered to be caused by the presence of high-molecular-weight polysaccharides (beta-glucans) in the mushrooms, although other constituents may also be involved. The total size of adenomas increased by 1.73 +/- 0.28 mm in the control group and decreased by -1.40 +/- 0.64 mm in the MAK group (P < .01). : The TLR2 agonist in polysaccharide-K is a structurally distinct lipid which acts synergistically with the protein-bound -glucan. J Nat Med 69 (2): 198-208, 2015. Mycologia 96 (4): 742-55, 2004 Jul-Aug. Chen S, Xu J, Liu C, et al. Clinical trials in cancer patients have demonstrated that G. lucidum products are generally well tolerated.[1]. In fact, the American Cancer Society (ACS) say that more than 100,000 people will receive a diagnosis of it in 2020. PSP and PSK appear to inhibit the growth of cancer cells. Akagi J, Baba H: PSK may suppress CD57(+) T cells to improve survival of advanced gastric cancer patients. What types of cancer might turkey tailmushrooms help fight? Fritz H et al. PolysaccharideK (PSK) is the best known active compoundin turkey tail mushrooms. [8] The development of improved Ganoderma products is currently under way using biotechnological processes.[9]. Miller RM, Taunton J: Targeting protein kinases with selective and semipromiscuous covalent inhibitors. Biochem Biophys Res Commun 330 (1): 46-52, 2005. P. Karst and Ganoderma sinense Zhao, Xu et Zhang. I believe they have extracts as well as capsules, and they are very knowledgeable. 79.0% (chemotherapy plus PSK) versus 72.2% (chemotherapy alone) (OR, 0.71; Jin X, Ruiz Beguerie J, Sze DM, et al. Because turkey tail is a fungus, anyone with a mushroom or mold allergy should not use it. Just be sure to carefully follow the instructions on the package. PSP may also stop the colon cancer cells from migrating and invading healthy cells, the study authors report. We need more studies, and we have to do more in the U.S., too.. Impact of Turkey Tail Mushroom in Pancreatic Cancer 8.1. In Japan, PSK is an approved mushroom product used to treat cancer. Trametes versicolor mushroom immune therapy in breast cancer. Hsu CL, Yu YS, Yen GC: Lucidenic acid B induces apoptosis in human leukemia cells via a mitochondria-mediated pathway. (2017). [1] Another Trametes species used primarily in China is Trametes robiniophila Murr, also known as Huaier. Medicinal mushrooms have been used for hundreds of years, mainly in Asian countries, for treatment of infections. Ikuzawa M, Matsunaga K, Nishiyama S, et al. (2014). Raja HA, Baker TR, Little JG, et al. Miller R, Galitsky NM, Duax WL, et al. However, the researchers found that a daily oral preparation containing Trametes versicolor powder improved immune status after standard treatment for breast cancer. Paul Stamets Talks About Curing Cancer With Mushrooms - Vitalherbs.co.uk [29] Triterpenoids also inhibit adhesion and migration of malignant cells. Oncotarget 8 (6): 10071-10084, 2017. Choose from 12 allied health programs at School of Health Professions. Liu RM, Zhong JJ: Ganoderic acid Mf and S induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells. Treatment did not significantly alter the mean mitogenic reactivity to phytohemagglutinin; mean counts of lymphocyte subsets CD3, CD4, CD8, and CD56; mean plasma concentrations on interleukin-2, interleukin-6, or interferon-gamma; or natural killer cell activity (P > .05). People, A common mushroom can alter gut bacteria and the production of blood sugar, a new study shows. Antioxidants reduce or inhibit cellular damage caused by oxidative stress, a condition caused by an imbalance between antioxidants and reactive molecules called free radical molecules. Her current research focuses on the use of the medicinal mushroom turkey tail (Trametes versicolor) for the treatment of breast and prostate cancer and the use of functional brain imaging to assess the treatment of brain cancer. In 2008, University of Haifa scientists announced that the Lingzhi mushroom, also known as Ganoderma lucidum, has medicinal value in treating breast and prostate cancer. These patients were monitored for up to 10 years after surgery. Mushrooms can strengthen the immune system. [15-17] Talk with your doctor or a healthcare provider about your interest in these mushrooms and if they might benefit you. A fraction of the dose appears to be orally absorbed, more or less intact, and is excreted in bile over several hours. inflammation. Many studies document chaga for its abilities to fight liver, breast, uterine, and gastric cancers. PSK helps to boost the immune system . Coriolus (trametes) Versicolor (Turkey Tail) Over 400 in vitro and animal studies of Coriolus versicolor extract have demonstrated that it stimulates the immune system, inhibits the growth of cancer cells, and acts as a strong antioxidant. Coriolus is a multicolored fungus that grows wild in various parts of the world and in the United States. It is used by contemporary Chinese physicians to support immune function in patients undergoing chemotherapy or radiation therapy for cancer, among other uses. You can add a little turkey tail mushroom powder to a smoothie or make a broth with it. Experience with Lion's Mane and Turkey Tail Mushrooms? In addition, other evidence indicates that PSP regulates the gut microbiome by balancing levels of healthy bacteria in the intestines. : Antitumor and anti-inflammatory activities of polysaccharides isolated from Ganoderma lucidum. CD69 expression on mononuclear lymphocytes after phytohemagglutinin stimulation was inhibited markedly compared with controls (P = .05) after a 24-hour incubation with lung cancer patient plasma. They think this may be because the two different mushrooms affect different biological processes. Chu KK, Ho SS, Chow AH. One review included preclinical studies conducted in In the study, a more-marked decrease in IAP level was observed in patients treated with PSK than in those treated in the control group. In Asian cultures, mushrooms are combined with herbal mixtures to treat cancer. 1). The authors suggest that turkey tail extract was the natural therapy most commonly prescribed to people with breast cancer, and they describe the extract as chemotherapy-compatible.. News at Bastyr | Bastyr University They are not normally severe, but they do exist.. They should only be used by people with cancer if recommended by their oncologist. PSP from turkey tail extract may inhibit colon cancer cell growth, according to some research. The PDQ Integrative, Alternative, and Complementary Therapies Editorial Board uses a formal evidence ranking system in developing its level-of-evidence designations. Log in to our secure, personalized website to manage your care (formerly myMDAnderson). Earth's First Foods - Turkey Tail ex Fr.) : Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer. In a subset analysis of patients with more than seven involved lymph nodes (pN3), the 5-year OS rate was significantly higher in the PSK group (47.8%) than that in the control group (22.8%; P = .0317). Anticancer Res 11 (2): 993-9, 1991 Mar-Apr. Learn about promising cancer treatments, from immunotherapy to, Depending on the type of cancer you have and the treatment you need, you may be able to manage some aspects of your cancer treatment at home. Finally, another small study has been reported since the meta-analysis. Turkey tail mushrooms are generally considered safe. Phase 1 clinical trial of Trametes versicolor in women with breast cancer. [4], PSK radiolabeled with carbon C-14 has been used to study the oral bioavailability and distribution of PSK in mice, rats, and rabbits. This summary is reviewed regularly and updated as necessary by the PDQ Integrative, Alternative, and Complementary Therapies Editorial Board, which is editorially independent of the National Cancer Institute (NCI). Another retrospective analysis of nonrandomized data evaluated 254 patients with gastric carcinoma undergoing curative surgery with postoperative adjuvant treatment in Japan. : A comprehensive review of the structure elucidation and biological activity of triterpenoids from Ganoderma spp. Heres what she wants cancer patients to know about medicinal mushrooms. These mushrooms may also provide other benefits, including: Research has shown that having a healthy colony of bacteria in the gut can help prevent disease and support the immune system. Noting that hosts become immunocompromised at the time of tumor progression and that decreased expression of major histocompatibility complex (MHC) class I by the tumor is one mechanism that allows it to evade destruction by cytotoxic T lymphocytes, investigators conducted a retrospective study to evaluate the expression of MHC class I by immunohistochemical staining in the primary lesions of patients with stage II or stage III gastric cancer. Turkey tail mushroom (Trametes Versicolor) has over 600 studies and 24 human clinical trials and appears in herbal texts dating back to the 16th century. Pancreatic cancer survivor Claudia uses her second chance This includes not only breast cancer, but lung, gastric, pancreatic and liver cancer as well. : Polysaccharide K and Coriolus versicolor extracts for lung cancer: a systematic review. The resulting two scores are then combined to produce an overall score. Reference citations in some PDQ cancer information summaries may include links to external websites that are operated by individuals or organizations for the purpose of marketing or advocating the use of specific treatments or products. Sci Rep. Aug 11 2016;6:29540. : Protection against lung cancer patient plasma-induced lymphocyte suppression by Ganoderma lucidum polysaccharides. The mean duration of follow-up was 49 months. One study showed that when people took mushrooms, they were able to tolerate more rounds chemotherapy treatment, probably because they have fewer side effects, and thereby it might have indirectly improved their survival, says Narayanan. Pinweha S, Wanikiat P, Sanvarinda Y, et al. (2012). However, not all of the research has been quite so enrcouraging. The typical high quality turkey tail mushroom supplements, like those found on our turkey tail supplements page, have a standard dose of 1 gram per capsule . Quayle K, Coy C, Standish L, et al. Medicinal mushrooms (PDQ)Health professional version. Permission to use images outside the context of PDQ information must be obtained from the owner(s) and cannot be granted by the National Cancer Institute. In this review article, the authors discuss the effects of a polysaccharide from Turkey Tail mushroom on cancer metastasis. [10-12] Most laboratory research studies have utilized G. lucidum products obtained via any of several extraction processes, which produce products that contain a mixture of two or more of these molecular species. Biotechnol Adv 21 (2): 109-22, 2003. Some studies actually used a lower dose than that. For 82 MHC expressionnegative patients with lymph node status of pN2 or greater, the RFS rates were 65% for the PSK group and 34% for the chemotherapy-only groupa significant difference with no P value offered. The best known constituent of turkey tail is the glycoprotein mixture known as PSK. Learn about our graduate medical education residency and fellowship opportunities. Sometimes the active ingredient is removed and sold as a supplement. One study analyzed outcomes from 101 patients at a single institution in Japan who had Dukes B or Dukes C colorectal cancer and were treated with UFT or UFT plus PSK for 24 months after curative surgery. Few adverse events have been reported in patients treated with PSK. Ganopoly was administered as 1,800 mg capsules 3 times daily before meals for 12 weeks. McCormick was impressed. Zhong L, et al. In some parts of the world, mushroom extracts are often used by patients for their medicinal benefits. Can Turkey Tail Mushrooms Help Fight Cancer? Treatment & Research Another group of investigators studied the effect of PSK added to tegafur/uracil (UFT) chemotherapy compared with that of UFT alone. There are no studies of G. lucidum with measured cancer outcomes. [18] Researchers compared 139 patients who received chemotherapy alone with 115 patients who received chemotherapy plus PSK. [13] Patients received either oral UFT 300 mg/d or UFT plus PSK 3 g/d for at least 1 year after undergoing gastric resection for stage II or stage III gastric cancer. Oncol Rep 7 (5): 1157-61, 2000 Sep-Oct. Wong CK, Bao YX, Wong EL, et al.
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