side effect of justicia carnea

Powdered sample (1000g) was soaked in absolute ethanol (3000mL) with constant stirring. Joseph, H., Gleye, J., Moulis, C., Fouraste, I., and Stanislas, E. O-Methoxylated C-glycosylflavones from Justicia pectoralis. In an acute exposure of experimental rats to single oral doses of extract, no mortality and signs of adverse effects were observed. Powdered sample was extracted using absolute ethanol and concentrated to obtain a slurry paste of J. carnea ethanol extracts. Nunes TRS, Cordeiro MF, Beserra FG, et al. Aim. However, scientifically it is called Justicia carnea. Justicia carnea is commonly cultivated and grown as an ornamental potted plant. Previously, J. carnea leaf has been reported to contain high quantity of phytochemical constituents (such as saponins, alkaloids and terpenoids), vitamins (A, C and E) and minerals [9, 10]. The haematological indices of the blood samples were determined using an automated URIT 2900 Plus 3 Differential Haematological Analyzer. Acute toxicity was determined in two phases using Lorke method. CAS Springer Nature. SOD is involved in the dismutation of the highly reactive superoxide anion to molecular oxygen (O2) and to less reactive hydrogen peroxides (H2O2) species, whereas CAT removes hydrogen peroxide (H2O2) and toxic hydroxyl radical into water molecule [35]. The aim of this study is to evaluate the safety of ethanol extract of J. carnea leaf assessing the hematology indices, organ antioxidant system and histology in healthy male wistar rats. As a consequence, depletion of reduced glutathione (GSH) either by removal from the cell or oxidation to GSSG could eventually lead to mild oxidative stress in cells and tissues [33, 34]. The Pharmacobiochemical Effects of Ethanol Extract of Justicia secunda Growing up, we were told many biblical stories, Negro pepper (Xylopia aethiopica) is a spice plant that possess several health benefits, which make it an indispensable, Eating for its sour taste when fairly ripen and sweet taste when well ripen, star apple finds favor, Fertility tree (Newbouldia laevis), also known as boundary tree, Ogirisi in Igbo, Adikuru in Hausa and Ewe akoko, Guava (Psidium guajava) is a well known tropical tree which is widely grown for its fruits. Another plant with this benefit is fertility tree. At the end of 14th day of administration, rats were allowed to fast overnight, sacrificed to collect samples for biochemical analysis and histopathological examination. Akintimehin, E.S., Karigidi, K.O., Omogunwa, T.S. While histology of organs showed no adverse pathological lesions in the internal organs of rats, higher dose (1200mg/kg) over a period of time could cause noticeable liver and kidney injury. Estimation of total, protein-bound, and non-protein sulfhydryl groups in tissues with Ellmans reagent. The aqueous leaf extract of ewe eje has demonstrated hypoglycaemic and antidiabetic properties; and thus, can be said to assist with blood sugar levels reduction. https://doi.org/10.3390/molecules191221442. There are several nutritional benefits of justicia carnea leaves. It creates the perfect environment for aphids and dried sod. et al. In this study, the aqueous leaf extract of Justicia carnea was used. Research reports it isn't capable of . Control treatment showed normal central venules without congestion, the morphology of the hepatocytes appear normal, the sinusoids appear normal with no observable form of infiltration and no observable pathological lesion seen. Rather it can assist with improveing liver function such as detoxification. It may also affect the activity of hormones. Although the antidepressant activity of justicia carnea has not been studied, and so may be hard to prove its efficacy scientifically, the leaves of justicia carnea have been used in traditional medicine to treat depression and anxiety disorder. Tissues were stained with haematoxylin and eosin, mounted on glass slides and examined under a standard light microscope. Ewe eje can also be used to manage abnormalities associated with anaemia and for the treatment and management of diabetics. J Ethnopharmacol. Authors KOK and ESA performed the statistical analysis and managed the analyses of study. 2007;39(1):4484. CAS In recent time, copious attention has been focused on the use of medicinal plants in the management and treatment of ailments such as anemia, diabetes and malaria. Ewe eje is safe and healthy for consumption. The research work was carried out in collaboration between all authors. The findings back up local assertions that they can be. Backfill the soil gently, filling the empty space around the root ball and then press it down with your hands. Kidney weight of rats treated with JCEE showed no significant difference with exception in 800mg/kg JCEE that demonstrated significant reduction. The hematopoietic systems represent a sensitive target of toxic compounds and an essential index of physiological and pathological status in experimental animals [24]. However, further research needs to done to determine the mode of action of the plant, and it's effects on humans. J Nat Prod 1988;51(3):599-600. The absorbance was taken at interval of 1min for 3min at 480nm. View abstract. If you provide us with your name, email address and the payment of a modest $25 annual membership fee, you will become a full member, enabling you to design and save up to 25 of your garden design ideas. Antioxidants & redox signaling Forum Review. PDF Biomedical Research 2019; 30 (4): 645-654 ISSN 0970-938X - Allied Academies Effect of Tectona grandis on phenylhydrazine induced anemia in rats. This is . While vitamin A maintains good vision, vitamin B are good for cellular functions such as metabolisms and energy production, and improve brain functioning. Keep in mind that natural products are not always necessarily safe and dosages can be important. Inhibitory Potential and Antidiabetic Activity of Leaf Extracts of Justicia carnea. Generally disease free. Bottom Line. How to make Ewe eje Extracthow to prepare justicia carnea. leaf inhibits interferon-γ secretion and has bacteriostatic activity against Acinetobacter baumannii and Klebsiella pneumoniae. Read also (Cashew leaves: health benefits and side effects of Anacardium occidentale). Google Scholar. Justicia carnea, the Brazilian plume flower, Brazilian-plume, flamingo flower, or jacobinia, is a flowering plant in the family Acanthaceae. The liver and kidney of rats administered with 500mg/kg JCEE and above demonstrated slight increase in MDA level with significant (P<0.05) increase only observed in the liver of rats that received 1200mg/kg of extract. The findings show that ethanol extracts of Costus afer and Justicia carnea could operate as main antioxidants and free radical scavengers. Star Apple: Amazing Health Benefits of eating its fruits. It has been reported previously that under certain conditions, dietary antioxidants such as ascorbic acid, tocopherol and carotenoids could act, occasionally, as pro-oxidants to initiate slight degree of oxidative stress microenvironment. Hepatic and renal damage has been recently linked with the use of medicinal plants in the treatment of various diseases [5, 6]. The result from the kidney histology could be due to the presence of active secondary metabolites and daily dosing of the extract. It is not. All rights reserved. Different researches performed on wistar rats has proven the non toxicity of justicia carnea. Ogbe RJ, Adoga GI, Abu AH. Fresh leaves of Justicia carnea were collected from Okitipupa area Ondo State. Toxicity studies of medicinal plants used in sub-Saharan Africa. It is obvious that Justicia carnea has potential antianemic, antioxidant, antidiabetic, hepatoprotective, and immune-boosting properties. International Journal of Biochemistry Research & Review. Studies have shown that ewe eje contains antioxidant and cardio-protective properties. 2007;112(1):13844. These compositions (metabolites and nutrients) are all responsible for the medicinal value and the health benefits of Justicia carnea. For some, the boiling method is preferred while for others, soaking in hot water is more convenient. The liver histopathological examination of the groups treated with J. carnea ethanol extract (JCEE) leaf showed normal liver architecture with slight abnormalities (such as mild fat congestion and hemorrhage) in the central venules of groups that received high doses. Rich on haematological and biochemical parameters in healthy Wistar rats. W Afr J Biol Sci. Deleting this collection CANNOT be undone. 10.9734/ijbcrr/2020/v29i630194. Onoagbe IO, Attah V, Luther MM, Esekheigbe A. Hypoglycemic and anti-diabetic effects of Morinda lucida and Tetracera alnifora in normal and streptozotocin-induced diabetic rats. if you add justicia carnea leaves in avocado seed tea, you may just get yourself the best remedy for cardiovascular diseases. DOI: https://doi.org/10.1089/ars.2007.1901. Despite living in close proximity to this plant, many individuals may be unaware of its benefits. Side effects of Ewe eje (Justicia carnea leaf Side Effects). 3 . The unique flower clusters and bright coloring has made it a popular choice among landscape artists and amateur gardeners as well. Justicia Carnea leaves extract contains a rich supply of iron, riboflavin, vitamins A, C, E, B1, B2, B9, and B12. Locklear, T. D., Huang, Y., Frasor, J., Doyle, B. J., Perez, A., Gomez-Laurito, J., and Mahady, G. B. Estrogenic and progestagenic effects of extracts of Justicia pectoralis Jacq., an herbal medicine from Costa Rica used for the treatment of menopause and PMS. and M.Sc. In these groups, from mild to severe order; the renal cortex appears distorted, Renal glomeruli and dillated capsular spaces appeared collapsed with characteristic pyknosis of the mesangial cells, The renal tubules, interstitial spaces, appears distorted with presence of red inflammatory cells, hemorrhagic cells infiltrating the renal interstitial spaces as well as focal sclerosis of renal glomeruli with associated degeration of the glomerular membrane (red arrows). Studies on the Phytochemical and Nutritional Composition of Aqueous Leaf Extract of Justicia Carnea and its Effect on Some Biochemical Parameters in Anaemic Rats. Superoxide dismutase was carried out using the method of Sun and Zigma [18]. 1. Stover PJ, Caudill MA. Liver and kidney are the main targets of toxicants because they are respectively involved in biotransformation and excretion of xenobiotics. It is cultivated and sold as a decorative potted plant and is planted in landscaping as a feature plant in warm . The results of this study suggests that ethanol extract of J. carnea leaf is relatively safe, could be beneficial in alleviating hematology related abnormalities without causing adverse effects on endogenous antioxidant system. It is also composed of vitamins and minerals good for heart health. A cup of ewe eje extract in the morning will provide you with energy needed to pull through the days activities. Anti-obesity, antioxidant and in silico evaluation of Justicia carnea Sun M, Zigma S. An improved spectrophotometer assay of superoxide dismutase based on epinephrine autoxidation. 400). Names of Justicia Betonica in various languages of the world are also given. Proximate analysis of the aqueous extract of J. carnea leaves showed that it contains appreciable amounts of 53.07 0.07% carbohydrate, 9.26 0.02% ash, and 26.71 0.02% . hindawi publishing corporation evidence-based complementary and alternative medicine. Photomicrograph of liver sections stained with haematoxylin and eosin (H & E) are presented in Fig. WBC reduced in rats treated with doses of J. carnea with significant decrease (p<0.05) in rats that received 50, 100 and 1200mg/kg body weight. We'll respect your privacy and unsubscribe at any time. Aim. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. J Ethnopharmacol. https://doi.org/10.1186/s40816-020-00234-4, DOI: https://doi.org/10.1186/s40816-020-00234-4. https://doi.org/10.1016/j.jada.2008.06.430. Fertility leaves: Benefits and side effects, Guava Leaf Tea: Health Benefits of Guava Leaves, Coriander seeds: 18 benefits Coriandrum sativum fruits and seeds, Rapini: Nutritional facts, benefits, side effects and care. Mr. E.S. PubMed Central Justicia carnea (ewe eje) is used by pregnant women to boost the production of red blood cells and cure anemia in pregnancy. Prepare the existing soil by breaking it up with a spade or hoe. Elevated activity of catalase in liver and kidney across tested doses of J. carnea ethanol extract showed no significant effect compared to the control. Leal, L. K., Ferreira, A. Each rat was dissected and blood samples were collected by cardiac puncture using 5mL into tubes containing ethylenediaminetetraacetic acid (EDTA) for hematological analysis. Generic and epigenetic contributions to human nutrition and health: managing genome-diet interactions. The principle is based on the formation of coloured complex when protein peptide interacts with cupric ions in an alkaline medium. Tietz NW. Phytochemical profile, antioxidant, -amylase inhibition, binding Macrocytic and hypochromic anemia usually results due to increased mean corpuscular volume (MCV) and decrease in mean corpuscular hemoglobin concentration [30]. Summer temperatures above 77 degrees Fahrenheit (25 C) are perfect. The protein content may help in cellular functions and are building blocks for structural and functional biomolecules. The leaves are also rich source of vitamin A, vitamin C, and vitamin E. Another plant with this composition is pumpkin fruit. Cardioprotective role of Justicia traquebareinsis Linn. Allium satium and Justicia carnea either used alone or co-administered had an ameliorating effect on cadmium toxicity. 2002;82:197205. Justicia carnea [jus-TEE-see-ah, KAR-nee-uh] is popularly known as the Brazilian Plume Flower. J Ethnopharmacol. Saunders; 1995. p. 26873. Akintimehin is a lecturer in the Biochemistry unit of Chemical Sciences Department, Olusegun Agagu University of Science and Technology, Okitipupa, Ondo State, Nigeria. The leaves of justicia carnea possess high content of iron and vitamin C. This compounds may be responsible for the blood boosting property of ewe eje leaves. The principle is based on the reduction of dichromate in a weak acid medium (acetic acid) to chromic acetate which is further heated in the presence of hydrogen peroxide to form an unstable intermediate (perchromic acid) that can be monitored spectrophotometrically at 620nm. California Privacy Statement, Evid Based Complement Alternat Med. The Hematological system and antioxidant status of rats following 14days of sub-acute exposure tolerated the ethanol extract of J. carnea leaf. what are the pros and cons of testosterone replacement therapy? -Amylase binding-interaction with JCAE was also investigated using fluorescence spectroscopy and molecular docking. The levels of white blood cell count, lymphocyte, granulocyte and MID could indicate that ethanol extract of J. carnea leaf pose no toxicity or sub acute inflammation to the overall defense mechanism and immunity of the experimental rats. J Nat Prod 1988;51(4):804-805. In conclusion, oral acute administration of J. carnea ethanol extract is safe because neither mortality nor any signs of toxicity were observed in experimental rats. Rich, well-drained soil retaining ample moisture is the perfect home for Brazilian plume flowers. Philadelphia: WB. PDF Haematological and Biochemical Studies on Justicia Carnea Leaves 16. Maturitas 2010;66(3):315-322. Paradoxically, oxidation of GSH has been reported to occur when GSH interact with metal ions thereby generating superoxide anions from the transfer of electrons from the metal ions to molecular oxygen [32]. Differences between means were considered to be significant at (p<0.05) using LSD (Least Square Difference) post hoc test. Justicia carnea and Cnidoscolus aconitifolius were tested for their capacity to ameliorate the fecundity of chloramphenicol-induced lymphoma in rats. Washington, DC: The National Academies Press; 1997. https://doi.org/10.17226/4988. Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J. Caterpillars may be an occasional problem, chewing down on some of the foliage. However, serious caution of the dose should be taken into consideration when extrapolating this result for human consumption. It is commonly referred to as blood root, blood booster, ewe eje in Yoruba, Ogwu obara in Igbo, and jacobinia in Brazil and south America. This claim by traditional healers with regard to the efficacy of justicia carnea in the treatment diabetes have been researched on and it was found to be true. Eyong EU, Umoh IB, Ebong PE, Eteng MU, Antai AB, Akpa AO. Justicia carnea is a medicinal plant that is used conventionally as blood tonic from time immemorial in Nigeria. A multidisciplinary overview of intoxicating snuff rituals in the western hemisphere. The possible anti-anaemic property of the leaf could be linked to the improved hemoglobin, PCV and RBC observed in this study. Why urban citizens in developing countries use traditional medicines: the case of suriname. As reported by science, Justicia carnea is composed of secondary metabolites such as: flavonoids, terpenoids, alkaloids, phenols, saponins and tannins. Justicia Carnea is a flowering plant that may be found in our neighborhood. 2016;5(1):6270 https://doi.org/10.1016/j.joad.2015.08.006. Aim. Niger J Physiol Sci. Biochemistry Unit, Department of Chemical Sciences, Olusegun Agagu University of Science and Technology, Okitipupa, Nigeria, Emmanuel Sina Akintimehin,Kayode Olayele Karigidi,Tope Samuel Omogunwa&Foluso Olutope Adetuyi, You can also search for this author in Walters DM., Cho Hye-Youn, Kleeberger SR. Oxidative Stress and Antioxidants in the Pathogenesis of Pulmonary Fibrosis: A Potential Role for Nrf2. Organic extract of Justicia pectoralis Jacq. Use liquid fertilizers, slow-release or granulated formulas. Justicia Carnea; Blood-Boosting Green Plant That Turns Hot Water Red! The compound responsible for this activity is lignan. Hepatoprotective Effect of Methanol Extract of Justicia carnea Leaves Several medicinal plants such as Xylopia aethiopica [25], Tectona grandis [26] and extracts of M. indica, A. hybridus and T. occidentalis [27] have also been reported to elevate RBC, hemoglobin and packed cell volume. International Journal of Phytomedicine and Phytotherapy, Clinical Phytoscience Effects of ethanol leaf extract of Justicia carnea on serum SOD Google Scholar. Anti-depressant-like effect of kaempferitrin isolated from Justicia spicigera Schltdl (Acanthaceae) in two behavior models in mice: evidence for the involvement of the serotonergic system. No observable focal sclerosis of renal glomeruli, capsular spaces around the glomerulus appears normal with distinct layering of renal microcellular structures. Justicia carnea is a popular ornamental plant, which possesses powerful medicinal values. Justicia carnea - Wikipedia Nutritive properties of aqueous extract Justicia carnea leaves and its effects on haematological and some biochemical indices of anaemia induced male wistar albino rats. 3. 400). The cuttings should be placed in individuals pots and put under glass or shaded location, away from direct sunlight. Keep an eye out for glasshouse red spider mite and glasshouse whitefly. The ability of glutathione to regenerate these dietary antioxidants has been linked to the redox state of glutathione disulphide-glutathione couple (GSSG/GSH) ratio [31]. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. J Ethnopharmacol 1985;13(1):3-49. https://doi.org/10.1016/j.jep.2005.06.013. Justicia carnea belongs to the family- Acanthaceae. Results obtained from the acute oral toxicity study revealed tolerance of experimental rat to acute administration of J. carnea ethanol extracts since no mortality and signs of toxicity were observed after 24h (Table1). Chidubem Olovo is a biochemist and a researcher whose interest is centered on the chemistry of natural products, their pharmacological properties and how using the plant sources can improve human healthy living. Mounanga MB, Mewonob L, Angone SA. Safety assessment of oral administration of ethanol extract of Justicia carnea leaf in healthy wistar rats: hematology, antioxidative and histology studies. Free radicals and antioxidants in normal physiological functions and human disease. We currently have no information for JUSTICIA PECTORALIS overview. It also increases good cholesterol levels. While every effort has been made to describe these plants accurately, please keep in mind that height, bloom time, and color may differ in various climates. https://doi.org/10.35841/biomedicalresearch.30-18-666. He is a research assistant in the Biochemistry Unit of the same Department. Fitoterapia. Methods. CAS It also grows in some Caribbean islands, including Trinidad and Tobago. Venancio, E. T., Rocha, N. F., Rios, E. R., Feitosa, M. L., Linhares, M. I., Melo, F. H., Matias, M. S., Fonseca, F. N., Sousa, F. C., Leal, L. K., and Fonteles, M. M. Anxiolytic-like effects of standardized extract of Justicia pectoralis (SEJP) in mice: Involvement of GABA/benzodiazepine in receptor.
Never Give Up Matsuoka Shuzo, Mr Rosson Royal Surrey Hospital, Articles S